Proteins

Proteins – The Building Blocks of Life

Proteins are complex biomolecules composed of amino acids. They are often called the “workhorses of the cell” because they perform a vast range of biological functions essential for life.


Table of Contents


What are Proteins?

Protein are high molecular weight nitrogen-containing biomolecules made up of amino acids linked together by peptide bonds. They play crucial roles in growth, repair, metabolism, immunity, and regulation of cellular activities.


Structure of Proteins

Protein are polymers of 20 different amino acids. Their structure is organized into four hierarchical levels:

Proteins
Proteins

1. Primary Structure

Linear sequence of amino acids joined by peptide bonds.

2. Secondary Structure

Regular folding into α-helix and β-pleated sheet stabilized by hydrogen bonds.

3. Tertiary Structure

Overall three-dimensional folding due to interactions between R-groups (disulfide bonds, ionic interactions).

4. Quaternary Structure

Association of two or more polypeptide chains (e.g., hemoglobin).


Types

  • Structural Protein: Collagen, Keratin (hair, skin, nails)
  • Transport Protein: Hemoglobin (oxygen transport)
  • Enzymes: Amylase, Pepsin (biological catalysts)
  • Defensive Protein: Antibodies
  • Signaling Protein: Insulin, growth hormones
  • Storage Protein: Ferritin (iron storage)

Functions

  • Catalyze biochemical reactions (enzymes)
  • Provide mechanical and structural support
  • Act as chemical messengers (hormones)
  • Defend the body against pathogens
  • Regulate metabolism and gene expression
  • Transport molecules across membranes and blood

Protein Denaturation

Denaturation is the loss of native protein structure due to heat, extreme pH, or chemicals. This results in loss of biological function.

Example: Cooking an egg causes denaturation of albumin.


Dietary Sources

Animal Sources

  • Eggs
  • Meat
  • Fish
  • Dairy products

Plant Sources

  • Legumes
  • Nuts
  • Soybean
  • Quinoa

Protein are essential for growth, muscle repair, enzyme synthesis, and immunity.


Practice Questions

Multiple Choice Questions

Q1. Protein are made up of:

a) Nucleotides   b) Amino acids   c) Fatty acids   d) Sugars

Answer: b) Amino acids

Q2. The bond linking amino acids is:

Answer: Peptide bond

True / False

  • All protein have the same amino acid sequence – ❌ False
  • Denaturation destroys protein function – ✅ True

Fill in the Blanks

  • Protein are polymers of Amino acids
  • 3D folding of protein is called Tertiary structure

FAQs

Why are protein important?
They are essential for growth, repair, enzymatic reactions, hormones, and immune defense.

What happens during protein denaturation?
The protein loses its native shape and biological activity.


Wikipedia – Protein Structure .


Summary

Proteins are indispensable biomolecules responsible for nearly every cellular function. Their specific structure determines their function, making them central to life processes such as metabolism, immunity, movement, and regulation.

Proteins aren’t just nutrients — they are molecular machines that keep life running.

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